PeptidePlaza
The Free Peptide Reference

Thymopentin

From PeptidePlaza, the free peptide reference · Entry #1028 · Nootropic · Sources fetched 2026-09-10 · Editorial standards

Thymopentin (also known as Timunox, Sintomodulina, Arg-Lys-Asp-Val-Tyr, Pentapeptide-1) is a nootropic research peptide. Thymopentin is an endogenous human peptide composed of five amino acid residues. It is currently investigational and studied for its role in immune modulation.

Thymopentin is a synthetic pentapeptide corresponding to the active site of thymopoietin, an endogenous human peptide. Its mechanism of action is thought to involve directing the assembly of the nuclear lamina, which helps maintain the structural organization of the nuclear envelope. It may also serve as a receptor for the attachment of lamin filaments to the inner nuclear membrane and could be involved in controlling the initiation of DNA replication through interaction with NAKAP95. Thymopentin is an investigational compound, with research exploring its potential in cancer immunotherapy and its safety profile.

1 Mechanism of action

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95

2 Chemical and physical properties

CAS number69558-55-0
Molar mass679.8 g/mol
Purity (typical)Not independently verified
Storage−20 °C, lyophilised powder, desiccated
SolubilitySterile water / bacteriostatic water

2.1 Amino acid sequence

RKDVY

3 Research studies (8)

  1. Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming
    Journal of nanobiotechnology (2024)
  2. Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression
    Biomaterials (2026)
  3. Thymic peptides for treatment of cancer patients
    The Cochrane database of systematic reviews (2011) · Meta-Analysis
  4. Thymopentin: safety overview
    Survey of immunologic research (1985) · RCT
  5. Evidence-Based Recommendations for Managing Atopic Dermatitis in Pediatric Patients: A Systematic Review and Meta-Analysis From the Pediatric Dermatology Special Interest Group of IADVL
    International journal of dermatology (2025) · Systematic Review
  6. Thymopentin in dermatology
    Current problems in dermatology (1989) · Review
  7. Thymopoietin to thymopentin: experimental studies
    Survey of immunologic research (1985) · Review
  8. [Immunostimulants--therapeutic aspects]
    Archiv fur Geschwulstforschung (1989) · Review

4 Safety and risk profile

4.1 Regulatory status

Thymopentin is currently classified as Investigational. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.

Safety data disclaimer. Safety assessments are based on published literature and are for educational reference only. Clinical evidence varies significantly between peptides. Always consult primary research and current regulatory guidance.

5 Frequently asked questions

What is Thymopentin?
Thymopentin is a synthetic pentapeptide that mimics the active site of thymopoietin, an endogenous human peptide. It is composed of five amino acid residues: Arginine, Lysine, Aspartic acid, Valine, and Tyrosine.
How does Thymopentin work?
Thymopentin is believed to help in the assembly of the nuclear lamina, which is crucial for maintaining the structural organization of the nuclear envelope. It may also act as a receptor for lamin filaments and could be involved in regulating the initiation of DNA replication by interacting with NAKAP95.
Is Thymopentin FDA approved?
No, Thymopentin is currently an investigational compound and has not been approved by the FDA for any medical use. Research is ongoing to understand its potential applications.
What is Thymopentin studied for?
Thymopentin is studied for its potential in various areas, including cancer immunotherapy, where it is explored for its role in modulating the tumor immune microenvironment. Its safety profile has also been a subject of research.

6 References

  1. Thymopentin — compound summary PubChem. View source
  2. Thymopentin — molecule record ChEMBL. View source
  3. Thymopentin — protein entry UniProt. View source
  4. Thymopentin — published literature (445 records) PubMed. View source

Related compounds

Entries that share a target, a mechanism, or a research area with Thymopentin.

Vasoactive Intestinal Peptidenootropic

Shares involved and through pharmacology

Vasoactive Intestinal Peptide (VIP) is a neuropeptide that activates VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2), which are G protein-coupled receptors.

SS-31anti-aging

Shares inner and membrane pharmacology

A cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane by binding cardiolipin. Protects mitochondrial cristae structure and reduces oxidative stress without scavenging ROS directly.

FOXO4-DRIanti-aging

Shares interaction and nuclear pharmacology

A mirror-image peptide that pries p53 away from FOXO4 inside senescent cells — removing the block that keeps those cells alive instead of apoptotic.

7 See also

For research reference only. Not medical advice. Peptides may be regulated or restricted in your jurisdiction. Entry validated by the PeptidePlaza Biomedical Research Desk; see editorial standards.