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Kisspeptin-10

Kisspeptin-10 (KP-10) — Reproductive Neuropeptide

Half-life: ~2–4 minutes (IV); rapid degradation

KP-10Metastin (1-10)KISS1 (112-121)

Research Profile

Research Depth
65
Potency
60
Half-Life Score
15
Selectivity
90
Stability
55

Relative research assessments — educational reference only.

Target Receptors

KISS1R (GPR54)

Critical Research Warning

Research chemical — not for human consumption. Potent reproductive-axis stimulant; do not use in pregnancy or in hormone-sensitive conditions without endocrine oversight.

PeptidePlaza Entry #026

"The active 10-amino-acid core of kisspeptin, a master regulator of reproductive hormone release. Stimulates GnRH secretion and has been studied in human trials for fertility and reproductive disorders."

Full Description

Kisspeptin-10 (KP-10) is the C-terminal decapeptide of kisspeptin, the product of the KISS1 gene, and the minimal sequence required for activation of the GPR54 (KISS1R) receptor. Kisspeptin signaling is a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis: it potently stimulates GnRH release, thereby driving LH and FSH secretion. Human clinical studies have explored KP-10 to trigger oocyte maturation in IVF, treat hypogonadotropic hypogonadism, and investigate reproductive and metabolic crosstalk. It has also been examined for bone metabolism because kisspeptin receptor signaling influences osteoblast and osteoclast activity.

Mechanism of Action

Binds the kisspeptin receptor (GPR54/KISS1R), a Gq-coupled GPCR, activating phospholipase C and calcium signaling in GnRH neurons, leading to GnRH secretion and downstream pituitary gonadotropin release.

Reported Benefits

  • • Potently stimulates GnRH/LH/FSH release in human studies
  • • Investigated as IVF trigger and fertility therapeutic
  • • Reveals metabolic–reproductive crosstalk
  • • Preclinical evidence for bone-protective effects

Potential Side Effects

  • • Injection site reactions
  • • Transient flushing
  • • Rare nausea
  • • Reproductive-hormone fluctuations

Frequently Asked Questions

What does kisspeptin-10 do?▼
KP-10 activates the GPR54 receptor, potently stimulating GnRH neurons in the hypothalamus. This drives LH and FSH release, making it a key regulator of reproduction and gonadal function.
How is kisspeptin-10 used in clinical research?▼
Human trials have used IV bolus KP-10 to trigger LH surges in IVF protocols, to stimulate the reproductive axis in hypogonadotropic hypogonadism, and to study the link between metabolism and fertility.
What is the typical dosing?▼
Clinical studies used IV administration of 0.1–3.2 nmol/kg (roughly 0.1–4 μg/kg). Subcutaneous research use is less standardized; peptide degradation is rapid.

For Research Reference Only

Not medical advice. Peptides may be regulated or restricted in your jurisdiction.

References

  1. 1.Metabolic regulation of kisspeptin - the link between energy balance and reproduction.. PubMed (2020). Navarro VM, et al.. pubmed.ncbi.nlm.nih.gov/32427949/ ↑
  2. 2.Pubertal development and regulation.. PubMed (2016). Abreu AP, et al.. pubmed.ncbi.nlm.nih.gov/26852256/ ↑
  3. 3.Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.. PubMed (2024). Li Z, et al.. pubmed.ncbi.nlm.nih.gov/38346942/ ↑
  4. 4.Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation.. PubMed (2018). Son HE, et al.. pubmed.ncbi.nlm.nih.gov/29391507/ ↑

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