PeptidePlaza
The Free Peptide Reference

Taltirelin

From PeptidePlaza, the free peptide reference · Entry #1125 · Nootropic · Sources fetched 2026-09-11 · Editorial standards

Taltirelin (also known as taltireline, TA 0910, taltirelina, taltirelinum) is a nootropic research peptide. Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog that acts as an agonist for the thyrotropin-releasing hormone receptor.

Taltirelin is a thyrotropin-releasing hormone receptor agonist, mimicking the action of natural TRH. It is currently in Phase 2 clinical trials. Research has explored its potential as a respiratory stimulant, particularly with arousal properties, and as a reversal agent for opioid-induced respiratory depression. Studies also investigate its role in inducing tyrosine hydroxylase (TH) expression by regulating TRHR and RAR in medium spiny neurons, and its potential application in the treatment of spinocerebellar degeneration.

1 Mechanism of action

Thyrotropin-releasing hormone receptor agonist (agonist)

Primary targets: Thyrotropin-releasing hormone receptor

2 Chemical and physical properties

CAS number103300-74-9
Molar mass405.4 g/mol
Purity (typical)Not independently verified
Storage−20 °C, lyophilised powder, desiccated
SolubilitySterile water / bacteriostatic water
Receptors / targetsThyrotropin-releasing hormone receptor

3 Research studies (8)

  1. A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
    Nature immunology (2024)
  2. Thyrotropin-releasing hormone analog as a stable upper airway-preferring respiratory stimulant with arousal properties
    Journal of applied physiology (Bethesda, Md. : 1985) (2022)
  3. Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression?
    Pharmacology research & perspectives (2022) · Review
  4. Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons
    Journal of translational medicine (2024)
  5. [Treatment for Spinocerebellar Degeneration]
    Brain and nerve = Shinkei kenkyu no shinpo (2023)
  6. A Comparison of Breathing Stimulants for Reversal of Synthetic Opioid-Induced Respiratory Depression in Conscious Rats
    The Journal of pharmacology and experimental therapeutics (2021)
  7. Diversity of thyrotropin-releasing hormone receptors in the pituitary and discrete brain regions of rats
    Japanese journal of pharmacology (1999)
  8. [Synthesis and pharmacological action of TRH analog peptide (Taltirelin)]
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica (1997) · Review

4 Safety and risk profile

4.1 Regulatory status

Taltirelin is currently classified as Phase 2 clinical trials. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.

Safety data disclaimer. Safety assessments are based on published literature and are for educational reference only. Clinical evidence varies significantly between peptides. Always consult primary research and current regulatory guidance.

5 Frequently asked questions

What is taltirelin?
Taltirelin is a synthetic analog of thyrotropin-releasing hormone (TRH). It functions as an agonist, meaning it activates the thyrotropin-releasing hormone receptor, mimicking the effects of the natural hormone.
How does taltirelin work?
Taltirelin works by acting as an agonist for the thyrotropin-releasing hormone receptor. This mechanism allows it to stimulate pathways associated with TRH, including inducing tyrosine hydroxylase expression by regulating TRHR and RAR in specific neurons.
What is taltirelin studied for?
Taltirelin is studied for its potential as a respiratory stimulant, particularly for its arousal properties, and as a reversal agent for opioid-induced respiratory depression. It is also investigated for its role in spinocerebellar degeneration and its ability to induce TH expression.
What is the regulatory status of taltirelin?
Taltirelin is currently in Phase 2 clinical trials. This indicates that it is undergoing further evaluation for its efficacy and safety in a larger group of people after initial safety assessments.

6 References

  1. Taltirelin — compound summary PubChem. View source
  2. Taltirelin — molecule record ChEMBL. View source
  3. Taltirelin — published literature (65 records) PubMed. View source

Related compounds

Entries that share a target, a mechanism, or a research area with Taltirelin.

Substance Pnootropic

Also nootropic

Substance P, also known as Neurokinin P, is an endogenous human peptide and a member of the tachykinin family.

Vasoactive Intestinal Peptidenootropic

Also nootropic

Vasoactive Intestinal Peptide (VIP) is a neuropeptide that activates VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2), which are G protein-coupled receptors.

Oxytocinapproved

Also nootropic

A nine-amino-acid neuropeptide hormone best known for childbirth and lactation, now studied extensively for social bonding, stress regulation, wound healing, and metabolic effects via intranasal delivery.

PT-141approved

Also nootropic

A cyclic heptapeptide melanocortin receptor agonist and active metabolite of Melanotan II. Unlike peripheral vasodilators, PT-141 acts centrally via the CNS to modulate arousal and food intake pathways.

Melanotan IInootropic

Also nootropic

A potent cyclic analog of α-MSH that activates melanocortin receptors broadly. Studied for UV-independent melanogenesis, appetite suppression, and as the parent compound of PT-141 (Bremelanotide).

Eptifibatideapproved

Also nootropic

Eptifibatide is an integrin alpha-IIb/beta-3 inhibitor used to decrease the rate of death or myocardial infarction in patients with acute coronary syndrome and those undergoing percutaneous coronary intervention.

7 See also

For research reference only. Not medical advice. Peptides may be regulated or restricted in your jurisdiction. Entry validated by the PeptidePlaza Biomedical Research Desk; see editorial standards.