GHRP-6
Growth Hormone Releasing Peptide-6
Half-life: ~20–30 minutes
Research Profile
Relative research assessments — educational reference only.
Target Receptors
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Research chemical — not for human consumption. GHRP-6 elevates cortisol and prolactin at higher doses and causes strong appetite stimulation. Banned by WADA.
"A synthetic ghrelin-mimetic hexapeptide that potently stimulates GH release through the ghrelin receptor. One of the first growth hormone secretagogues developed, with over 25 years of research history."
Full Description
GHRP-6 is a synthetic hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) developed in the 1980s as a growth hormone secretagogue. It acts as a ghrelin receptor (GHS-R1a) agonist, potently stimulating pituitary GH release and amplifying GH pulse amplitude. Beyond its endocrine effects, research has explored its cytoprotective and tissue-repair actions, including cardioprotection, wound healing, and organ-protective effects in ischemia models. It was the first GHRP to reach clinical testing and remains a widely studied reference compound in GH research.
Mechanism of Action
Binds the growth hormone secretagogue receptor (GHS-R1a), activating phospholipase C and intracellular calcium release, leading to GH exocytosis from pituitary somatotrophs. Also activates hypothalamic GHRH neurons and suppresses somatostatin tone.
Reported Benefits
- • Potent GH release in clinical and preclinical studies
- • Amplifies endogenous GH pulse amplitude
- • Cardioprotective effects in ischemia models
- • Tissue-repair and organ-protection research
Potential Side Effects
- • Marked appetite stimulation (ghrelin agonism)
- • Cortisol and prolactin elevation at higher doses
- • Transient blood pressure changes
- • Injection site reactions
Frequently Asked Questions
How does GHRP-6 increase growth hormone?▼
What else is GHRP-6 studied for?▼
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For Research Reference Only
Not medical advice. Peptides may be regulated or restricted in your jurisdiction.
References
- 1.Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms.. PubMed (2024). Berlanga-Acosta J, et al.. pubmed.ncbi.nlm.nih.gov/38873418/ ↑
- 2.Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure.. PubMed (2006). Cibrián D, et al.. pubmed.ncbi.nlm.nih.gov/16417467/ ↑
- 3.Growth hormone-releasing peptide (GHRP).. PubMed (1998). Bowers CY, et al.. pubmed.ncbi.nlm.nih.gov/9893708/ ↑
- 4.Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.. PubMed (2025). Zhao X, et al.. pubmed.ncbi.nlm.nih.gov/41327290/ ↑
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