AOD-9604
Modified hGH Fragment 177-191 (Lipolytic)
Half-life: ~10–15 minutes (IV); rapid clearance
Research Profile
Relative research assessments — educational reference only.
Target Receptors
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Research chemical — not for human consumption. Banned by WADA; athletes should be aware of doping-testing implications. No approved human indication exists.
"A modified C-terminal fragment of human growth hormone (amino acids 177-191) with a tyrosine substitution. Studied primarily for its lipolytic (fat-burning) effects without the growth-promoting activity of full-length hGH."
Full Description
AOD-9604 is a synthetic peptide corresponding to the lipolytic region of human growth hormone (hGH fragment 177-191) with a single amino acid modification (Tyr at position 180) intended to stabilize the molecule. In rodent studies, chronic AOD-9604 treatment reduced body weight and fat mass in obese mice via stimulation of lipolysis, without affecting linear growth or IGF-1 levels. It has been investigated as an anti-obesity agent and, more recently, in preclinical models for cartilage and joint applications. It is a common target of sports drug testing because of its association with performance-enhancing peptide use.
Mechanism of Action
Mimics the lipolytic action of the C-terminal region of hGH: activates lipolysis in adipocytes, promoting free fatty acid release, while lacking the N-terminal growth-promoting domain that drives IGF-1 secretion and linear growth.
Reported Benefits
- • Reduced body weight and fat mass in rodent obesity models
- • Stimulates lipolysis without promoting IGF-1-dependent growth
- • Preclinical evidence in cartilage / joint repair models
- • Well-characterized analytically for detection studies
Potential Side Effects
- • Injection site reactions
- • Limited human safety data
- • Potential blood glucose effects in sensitive models
Frequently Asked Questions
How does AOD-9604 differ from full hGH?▼
Is AOD-9604 approved for any use?▼
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For Research Reference Only
Not medical advice. Peptides may be regulated or restricted in your jurisdiction.
References
- 1.The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.. PubMed (2001). Heffernan M, et al.. pubmed.ncbi.nlm.nih.gov/11713213/ ↑
- 2.Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model.. PubMed (2015). Kwon DR, et al.. pubmed.ncbi.nlm.nih.gov/26275694/ ↑
- 3.AOD-9604 Metabolic.. PubMed (2004). Wilding J, et al.. pubmed.ncbi.nlm.nih.gov/15134286/ ↑
- 4.Detection and in vitro metabolism of AOD9604.. PubMed (2015). Cox HD, et al.. pubmed.ncbi.nlm.nih.gov/25208511/ ↑
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