Exenatide
From PeptidePlaza, the free peptide reference · Entry #1037 · Metabolic · Sources fetched 2026-09-10 · Editorial standards
Exenatide (also known as Bydureon Pen, Byetta, Bydureon, Exendin 4) is a metabolic research peptide. Exenatide is a synthetic peptide that acts as a glucagon-like peptide-1 (GLP-1) receptor agonist, primarily studied for its role in metabolic regulation.
Exenatide is a synthetic peptide belonging to the class of incretin mimetics, specifically a glucagon-like peptide-1 (GLP-1) receptor agonist. It functions by mimicking the effects of natural GLP-1, which include stimulating insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety. Exenatide is investigational and has been the subject of numerous studies, including randomized clinical trials comparing its efficacy and safety against other treatments for type 2 diabetes. Research also explores its potential effects on non-motor symptoms in Parkinson's disease, highlighting its broader therapeutic interest beyond metabolic disorders.
1 Chemical and physical properties
| CAS number | 141758-74-9 |
|---|---|
| Molar mass | 4187 g/mol |
| Purity (typical) | Not independently verified |
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
1.1 Amino acid sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
2 Research studies (8)
- Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial
Diabetes care (2018) · RCT - Exenatide
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists (2006) · Review - Exenatide
Expert opinion on pharmacotherapy (2007) · Review - Exenatide
(2006) · Review - What Effects Might Exenatide have on Non-Motor Symptoms in Parkinson's Disease: A Post Hoc Analysis
Journal of Parkinson's disease (2018) · RCT - Exenatide
(2012) · Review - Exenatide
(2026) - A double-blind, placebo-controlled trial of exenatide for the treatment of olanzapine-related weight gain in obese and overweight adults
Journal of affective disorders (2025) · RCT
3 Safety and risk profile
3.1 Regulatory status
Exenatide is currently classified as Investigational. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.
4 Frequently asked questions
- What is Exenatide?
- Exenatide is a synthetic peptide that functions as a glucagon-like peptide-1 (GLP-1) receptor agonist. It is classified as an incretin mimetic, designed to replicate the actions of the natural hormone GLP-1 in the body.
- How does Exenatide work?
- Exenatide works by activating GLP-1 receptors. This activation leads to several physiological effects, including stimulating the release of insulin, inhibiting the secretion of glucagon, slowing down the rate at which the stomach empties, and increasing feelings of fullness.
- What is Exenatide studied for?
- Exenatide is primarily studied for its role in managing type 2 diabetes, with research comparing its efficacy and safety against other treatments. Additionally, studies have investigated its potential effects on non-motor symptoms in Parkinson's disease.
- Is Exenatide FDA approved?
- Exenatide is currently an investigational compound. Its regulatory status indicates that it is still undergoing research and evaluation, and it has not yet received FDA approval.
5 References
- Exenatide — compound summary PubChem. View source
- Exenatide — molecule record ChEMBL. View source
- Exenatide — published literature (2,848 records) PubMed. View source
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