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Ceruletide Diethylamine

From PeptidePlaza, the free peptide reference · Entry #1059 · Metabolic · Sources fetched 2026-09-10 · Editorial standards

Ceruletide Diethylamine (also known as Caerulein diethylamine, Ceosunin, Takus, Tymtran) is a metabolic research peptide. Ceruletide Diethylamine is a cholecystokinin A receptor agonist that was FDA approved in 1982.

Ceruletide Diethylamine, also known as Caerulein diethylamine, is a synthetic peptide that acts as an agonist for the cholecystokinin A receptor. It has been studied for its effects in conditions such as schizophrenia and acute pancreatitis. Research also includes dose-response studies using scintigraphic techniques and investigations into its impact on biliary tract complications. The compound was first approved by the FDA in 1982.

1 Mechanism of action

Cholecystokinin A receptor agonist (agonist)

Primary targets: Cholecystokinin A receptor

2 Chemical and physical properties

CAS number71247-25-1
Molar mass1425.5 g/mol
Purity (typical)Not independently verified
Storage−20 °C, lyophilised powder, desiccated
SolubilitySterile water / bacteriostatic water
Receptors / targetsCholecystokinin A receptor

3 Research studies (8)

  1. Biliary tract complications in patients with hypoganglionosis and chronic idiopathic intestinal pseudoobstruction syndrome
    Journal of pediatric surgery (1993) · Case Series
  2. Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat
    The Journal of clinical investigation (1983)
  3. The effects of ceruletide in schizophrenia
    Archives of general psychiatry (1984) · RCT
  4. Ceruletide intravenous dose-response study by a simplified scintigraphic technique
    AJR. American journal of roentgenology (1985)
  5. [Antipsychotic action of ceruletide diethylamine (caerulein), a substance resembling CCK-8]
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica (1983)
  6. Reflux sign in cholescintigraphy after administration of a gallbladder contracting agent
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine (1989)
  7. [Exocrine secretion of pancreas after the administration of ceruletide diethylamine, cholecystokinin-pancreozymin and tetragastrin in rats (author's transl)]
    Nihon Ika Daigaku zasshi (1981)
  8. Ceruletide, a cholecystokinin-related peptide, attenuates haloperidol-induced increase in dopamine release from the rat striatum: an in vivo microdialysis study
    Brain research (1990)

4 Safety and risk profile

4.1 Regulatory status

Ceruletide Diethylamine is currently classified as FDA approved. Approval applies to specific clinical indications and dosing; research-grade material is not the approved product.

Safety data disclaimer. Safety assessments are based on published literature and are for educational reference only. Clinical evidence varies significantly between peptides. Always consult primary research and current regulatory guidance.

5 Frequently asked questions

What is Ceruletide Diethylamine?
Ceruletide Diethylamine is a synthetic peptide that functions as an agonist for the cholecystokinin A receptor. It is also known by the name Caerulein diethylamine.
How does Ceruletide Diethylamine work?
Ceruletide Diethylamine works by acting as an agonist for the cholecystokinin A receptor. This means it binds to and activates this specific receptor, mimicking the effects of its natural ligand.
Is Ceruletide Diethylamine FDA approved?
Yes, Ceruletide Diethylamine was approved by the FDA in 1982. This indicates it has met the regulatory standards for safety and efficacy at the time of its approval.
What has Ceruletide Diethylamine been studied for?
Ceruletide Diethylamine has been studied for its potential effects in conditions such as schizophrenia and acute pancreatitis. Research has also explored its use in dose-response studies and its impact on biliary tract complications.

6 References

  1. Ceruletide Diethylamine — compound summary PubChem. View source
  2. Ceruletide Diethylamine — molecule record ChEMBL. View source
  3. Ceruletide Diethylamine — published literature (11 records) PubMed. View source

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7 See also

For research reference only. Not medical advice. Peptides may be regulated or restricted in your jurisdiction. Entry validated by the PeptidePlaza Biomedical Research Desk; see editorial standards.