Seractide Acetate
From PeptidePlaza, the free peptide reference · Entry #1084 · Metabolic · Sources fetched 2026-09-11 · Editorial standards
Seractide Acetate (also known as Acthar Gel-Synthetic, Seractid acetat hydrat, Seractide acetate hydrate, Seractide acetate [USAN]) is a metabolic research peptide. Seractide Acetate is a synthetic peptide that acts as a melanocortin receptor 2 agonist.
Seractide Acetate, also known as Acthar Gel-Synthetic, is a synthetic peptide and a melanocortin receptor 2 agonist. It was first approved by the FDA in 1978. Research on Seractide Acetate and related compounds has explored its role in various biological processes, including its potential influence on tumour-associated macrophages in hepatocellular carcinoma metastasis and its capacity to bolster T-cell effector function in breast cancer. Studies also investigate how exogenous acetate attenuates inflammatory responses through HIF-1α-dependent glycolysis regulation in macrophages. The compound has been the subject of extensive scientific literature.
1 Mechanism of action
Melanocortin receptor 2 agonist (agonist)
Primary targets: Melanocortin receptor 2
2 Chemical and physical properties
| Molar mass | 4619 g/mol |
|---|---|
| Purity (typical) | Not independently verified |
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
| Receptors / targets | Melanocortin receptor 2 |
3 Research studies (8)
- Tumour-associated macrophages serve as an acetate reservoir to drive hepatocellular carcinoma metastasis
Nature metabolism (2025) - Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer
Nature cancer (2023) - Exogenous acetate attenuates inflammatory responses through HIF-1α-dependent glycolysis regulation in macrophage
Cellular and molecular life sciences : CMLS (2024) - Amyl Acetate and Isoamyl Acetate
International journal of toxicology (2023) - Acetate-mediated effects of ethanol
Alcoholism, clinical and experimental research (1994) · Review - Acetate Metabolism in Urological Health and Disease
Serican journal of medicine (2024) - Ulipristal acetate: in uterine fibroids
Drugs (2012) · Review - Bacterial acetate metabolism and its influence on human epithelia
Emerging topics in life sciences (2024) · Review
4 Safety and risk profile
4.1 Regulatory status
Seractide Acetate is currently classified as FDA approved. Approval applies to specific clinical indications and dosing; research-grade material is not the approved product.
5 Frequently asked questions
- What is Seractide Acetate?
- Seractide Acetate is a synthetic peptide that functions as an agonist for the melanocortin receptor 2. It is also known by the name Acthar Gel-Synthetic.
- How does Seractide Acetate work?
- Seractide Acetate works by acting as a melanocortin receptor 2 agonist. This means it binds to and activates the melanocortin receptor 2, initiating a cellular response.
- Is Seractide Acetate FDA approved?
- Yes, Seractide Acetate is FDA approved. It received its first approval in 1978.
- What is Seractide Acetate studied for?
- Seractide Acetate is studied for its potential roles in various biological processes, including its influence on tumour-associated macrophages in hepatocellular carcinoma metastasis and its ability to enhance T-cell effector function in breast cancer. Research also investigates its effects on inflammatory responses.
6 References
- Seractide Acetate — compound summary PubChem. View source
- Seractide Acetate — molecule record ChEMBL. View source
- Seractide Acetate — published literature (182,607 records) PubMed. View source
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