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Substance P

From PeptidePlaza, the free peptide reference · Entry #1038 · Nootropic · Sources fetched 2026-09-10 · Editorial standards

Substance P (also known as Neurokinin P, Neuropeptide sp-1, Sh-oligopeptide-73, Substance p (1-11)) is a nootropic research peptide. Substance P, also known as Neurokinin P, is an endogenous human peptide and a member of the tachykinin family.

Substance P is an endogenous human peptide belonging to the tachykinin family. It functions by exciting neurons, evoking behavioral responses, acting as a potent vasodilator and secretagogue, and contracting various smooth muscles. With over 24,000 papers, it is a well-studied compound, with research exploring its role as a "Friend or Foe" in clinical medicine and its broader pharmacological implications. It is currently in an investigational regulatory status.

1 Mechanism of action

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

2 Chemical and physical properties

CAS number33507-63-0
Molar mass1347.6 g/mol
Purity (typical)Not independently verified
Storage−20 °C, lyophilised powder, desiccated
SolubilitySterile water / bacteriostatic water

2.1 Amino acid sequence

RPKPQQFFGLM

3 Research studies (8)

  1. Substance P-Friend or Foe
    Journal of clinical medicine (2022)
  2. Substance P
    Pharmacological reviews (1983) · Review
  3. Substance P
    Lancet (London, England) (1976)
  4. Substance P
    European journal of pain (London, England) (2000) · Review
  5. Substance P
    British medical bulletin (1982) · Review
  6. Substance P
    Vitamins and hormones (1977) · Review
  7. Substance P
    Life sciences (1974) · Review
  8. The Regenerative Potential of Substance P
    International journal of molecular sciences (2022) · Review

4 Safety and risk profile

4.1 Regulatory status

Substance P is currently classified as Investigational. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.

Safety data disclaimer. Safety assessments are based on published literature and are for educational reference only. Clinical evidence varies significantly between peptides. Always consult primary research and current regulatory guidance.

5 Frequently asked questions

What is Substance P?
Substance P, also known as Neurokinin P, is an endogenous human peptide. It is classified as a tachykinin, a family of active peptides that play various roles in the body.
How does Substance P work?
Substance P functions by exciting neurons and evoking behavioral responses. It is also a potent vasodilator, meaning it widens blood vessels, and a secretagogue, which stimulates secretion. Additionally, it can contract many smooth muscles, either directly or indirectly.
What is the regulatory status of Substance P?
Substance P is currently in an investigational regulatory status. This means it is still undergoing research and development and has not yet received approval for widespread clinical use.
What is Substance P studied for?
Substance P is extensively studied, with research exploring its multifaceted roles in the body, including its potential as both beneficial and detrimental in clinical medicine. Its pharmacological properties, such as its effects on neurons, blood vessels, and smooth muscles, are also key areas of investigation.

6 References

  1. Substance P — compound summary PubChem. View source
  2. Substance P — molecule record ChEMBL. View source
  3. Substance P — protein entry UniProt. View source
  4. Substance P — published literature (24,333 records) PubMed. View source

Related compounds

Entries that share a target, a mechanism, or a research area with Substance P.

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7 See also

For research reference only. Not medical advice. Peptides may be regulated or restricted in your jurisdiction. Entry validated by the PeptidePlaza Biomedical Research Desk; see editorial standards.