Ipamorelin
Selective GH Secretagogue
Half-life: ~2 hours
Research Profile
Relative research assessments — educational reference only.
Target Receptors
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For educational reference only. While Ipamorelin has the cleanest selectivity profile of all GHSRs, long-term GH/IGF-1 elevation effects on cancer risk remain a theoretical concern.
"A pentapeptide ghrelin mimetic renowned for its exceptional receptor selectivity. Unlike other GHSRs, Ipamorelin does not significantly raise cortisol, ACTH, or prolactin — making it a clean research tool for isolated GH axis studies."
Full Description
Ipamorelin is a pentapeptide growth hormone secretagogue (GHS) that acts as a selective agonist of the growth hormone secretagogue receptor (GHSR-1a). Its defining characteristic is its exceptional hormonal selectivity: at effective GH-releasing doses, it does not significantly elevate cortisol, ACTH, aldosterone, or prolactin — unlike older GHRPs (GHRP-2, GHRP-6) which non-selectively activate multiple neuroendocrine pathways. This selectivity makes it a valuable research model for studying isolated GH axis effects. It exhibits a short half-life (~2h) with rapid, physiological GH pulses.
Mechanism of Action
Selective agonist of GHSR-1a (ghrelin receptor) in pituitary and hypothalamus. Stimulates pulsatile GH release without activating downstream ACTH or cortisol pathways. Synergizes with GHRH analogs (e.g., CJC-1295).
Reported Benefits
- • Selective GH release without cortisol or ACTH elevation
- • Increased bone mineral density in animal models
- • Synergistic GH amplification when co-administered with GHRH analogs
- • Preserves physiological pulsatile GH release pattern
Potential Side Effects
- • Transient hunger (ghrelin receptor activation)
- • Injection site reactions
- • Headache in some protocols
- • Water retention at high doses
Frequently Asked Questions
What makes Ipamorelin different from other GHRPs?▼
Why is it usually paired with CJC-1295?▼
How long does the GH elevation last?▼
For Research Reference Only
Not medical advice. Peptides may be regulated or restricted in your jurisdiction.
References
- 1.The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism. PubMed (2024). Lu Z, et al.. pubmed.ncbi.nlm.nih.gov/39043357/ ↑
- 2.The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus. PubMed (2024). Gouda M, et al.. pubmed.ncbi.nlm.nih.gov/38996787/ ↑
- 3.Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin. PubMed (2015). Semenistaya E, et al.. pubmed.ncbi.nlm.nih.gov/25869809/ ↑
- 4.Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. PubMed (2014). Beck DE, et al.. pubmed.ncbi.nlm.nih.gov/25331030/ ↑
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