Acyline
From PeptidePlaza, the free peptide reference · Entry #1027 · Anti-Aging · Sources fetched 2026-09-10 · Editorial standards
Acyline (also known as MER-104) is a anti-aging research peptide. Acyline is a synthetic peptide and a gonadotropin-releasing hormone (GnRH) antagonist, currently under investigation.
Acyline is a synthetic peptide that functions as a gonadotropin-releasing hormone (GnRH) antagonist. It works by reversibly downregulating the hypothalamic-pituitary-gonadal axis. Research has explored its use in various animal models, including studies on the selection and growth of dominant follicles in bovine and equine reproduction. It has also been investigated for the reversible downregulation of the hypothalamic-pituitary-gonadal axis in stallions. Acyline is an investigational compound, with studies focusing on its role in reproductive physiology and its potential as a GnRH antagonist.
1 Chemical and physical properties
| CAS number | 170157-13-8 |
|---|---|
| Molar mass | 1533.2 g/mol |
| Purity (typical) | Not independently verified |
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
2 Research studies (8)
- Necessity for LH in selection and continued growth of the bovine dominant follicle
Reproduction (Cambridge, England) (2020) - Development of the "waveless" bovine model
Animal reproduction science (2018) - Delivery of Peptidic Gonadotropin Releasing Hormone Antagonists
Current drug delivery (2018) · Review - Positive effect of FSH but not LH on early development of the dominant follicle in mares
Reproduction, fertility, and development (2010) - Reversible downregulation of the hypothalamic-pituitary-gonadal axis in stallions with a novel GnRH antagonist
Theriogenology (2016) - Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist
The Journal of clinical endocrinology and metabolism (2002) · RCT - Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics
Cancer chemotherapy and pharmacology (2009) - Treatment of canine pyometra with the gonadotropin-releasing hormone antagonist acyline: a case series
Topics in companion animal medicine (2015)
3 Safety and risk profile
3.1 Regulatory status
Acyline is currently classified as Investigational. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.
4 Frequently asked questions
- What is Acyline?
- Acyline is a synthetic peptide. It is classified as a gonadotropin-releasing hormone (GnRH) antagonist, meaning it blocks the action of GnRH.
- How does Acyline work?
- Acyline works by acting as a gonadotropin-releasing hormone (GnRH) antagonist. This mechanism leads to the reversible downregulation of the hypothalamic-pituitary-gonadal axis, influencing reproductive hormone regulation.
- What is Acyline studied for?
- Acyline is studied for its effects on reproductive physiology, particularly in animal models. Research includes its role in the selection and growth of dominant follicles in bovine and equine species, and the reversible downregulation of the hypothalamic-pituitary-gonadal axis in stallions.
- Is Acyline FDA approved?
- No, Acyline is not FDA approved. It is currently an investigational compound, meaning it is still in the research and development phase.
5 References
- Acyline — compound summary PubChem. View source
- Acyline — molecule record ChEMBL. View source
- Acyline — published literature (102 records) PubMed. View source
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