Bombesin
From PeptidePlaza, the free peptide reference · Entry #1041 · Metabolic · Sources fetched 2026-09-10 · Editorial standards
Bombesin (also known as Bombesin 14, Alytesin, 2-L-glutamine-6-L-asparagine-, Dihydrochloride, Bombesin, Bombesin trifluoroacetate salt) is a metabolic research peptide. Bombesin is a tetradecapeptide that acts as a bombesin receptor agonist, influencing various physiological processes.
Bombesin is a naturally occurring tetradecapeptide that functions as an agonist for bombesin receptors. It is known to affect gastrointestinal function, thermoregulation, and endocrine activity. Research into bombesin has explored its potential in gastroprotection and its role in modulating thyroxine 5'-deiodinase activity in brown adipose tissue. The compound is currently investigational, with studies also focusing on its application in targeted therapy, particularly for small cell lung cancer, through bombesin-drug conjugates. The literature frequently reviews the pharmacology and physiology of bombesin-like peptides and their receptors.
1 Chemical and physical properties
| CAS number | 31362-50-2 |
|---|---|
| Molar mass | 1619.9 g/mol |
| Purity (typical) | Not independently verified |
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
1.1 Amino acid sequence
Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
2 Research studies (8)
- Bombesin-induced gastroprotection
Annals of surgery (2005) · Review - Biochemistry, Bombesin
(2026) - Impairment of cold-induced increase in thyroxine 5'-deiodinase activity in mouse brown adipose tissue by the intracerebroventricular administration of bombesin
Peptides (1992) - Bombesin-drug conjugates in targeted therapy for small cell lung cancer
American journal of cancer research (2022) · Review - Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology
Current opinion in endocrinology, diabetes, and obesity (2015) · Review - Biology of mammalian bombesin-like peptides and their receptors
Current opinion in endocrinology, diabetes, and obesity (2011) · Review - Direct antimicrobial activities of PR-bombesin
Life sciences (2006) - Effects of bombesin on behavior
Life sciences (1985)
3 Safety and risk profile
3.1 Regulatory status
Bombesin is currently classified as Investigational. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.
4 Frequently asked questions
- What is Bombesin?
- Bombesin is a naturally occurring tetradecapeptide. It functions as an agonist for bombesin receptors, influencing various physiological processes within the body.
- How does Bombesin work?
- Bombesin works by acting as an agonist for bombesin receptors. This interaction allows it to modulate a range of biological activities, including those related to gastrointestinal function, thermoregulation, and endocrine systems.
- What is Bombesin studied for?
- Bombesin is studied for its potential in gastroprotection and its influence on thyroxine 5'-deiodinase activity. It is also being investigated for its use in targeted therapy, specifically in the context of small cell lung cancer, through bombesin-drug conjugates.
- Is Bombesin FDA approved?
- No, Bombesin is currently an investigational compound and has not received FDA approval for any therapeutic uses.
5 References
- Bombesin — compound summary PubChem. View source
- Bombesin — molecule record ChEMBL. View source
- Bombesin — published literature (4,745 records) PubMed. View source
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