Lypressin
From PeptidePlaza, the free peptide reference · Entry #1058 · Metabolic · Sources fetched 2026-09-10 · Editorial standards
Lypressin (also known as Lysine vasopressin, 8-L-Lysinevasopressin, Lipresina, Lypressine) is a metabolic research peptide. Lypressin is a synthetic peptide and a vasopressin receptor agonist, used in the treatment of diabetes insipidus.
Lypressin, also known as Lysine vasopressin, is a synthetic peptide that functions as a vasopressin receptor agonist. It is FDA approved and was first approved in 1982. Lypressin is studied for its hemodynamic effects, particularly in conditions like orthostatic hypotension. Research also explores its role among vasopressin analogues and its safety and tolerability in various treatments, including those for allergic rhinitis in children. The compound is also mentioned in reviews concerning hepatorenal syndrome and septic shock.
1 Mechanism of action
Vasopressin receptor agonist (agonist)
Primary targets: Vasopressin receptor
2 Chemical and physical properties
| CAS number | 50-57-7 |
|---|---|
| Molar mass | 1056.2 g/mol |
| Purity (typical) | Not independently verified |
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
| Receptors / targets | Vasopressin receptor |
3 Research studies (8)
- Hepatorenal Syndrome
Clinical journal of the American Society of Nephrology : CJASN (2019) · Review - Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides
International journal of molecular sciences (2022) · Review - Hemodynamic effects of lysine-vasopressin in orthostatic hypotension
American journal of kidney diseases : the official journal of the National Kidney Foundation (1985) - Safety and tolerability of treatments for allergic rhinitis in children
Drug safety (2004) · Review - Terlipressin: vasopressin analog and novel drug for septic shock
The Annals of pharmacotherapy (2006) · Review - Lypressin (Diapid) and other drugs for diabetes insipidus
The Medical letter on drugs and therapeutics (1972) - Quantitative analysis of nonapeptides in pharmaceutical dosage forms by high-performance liquid chromatography
Journal of chromatography (1977) - The effect of 6-hydroxydopamine and some hypotensive drugs on lypressin induced hypertension in rats
Polish journal of pharmacology and pharmacy (1985)
4 Safety and risk profile
4.1 Regulatory status
Lypressin is currently classified as FDA approved. Approval applies to specific clinical indications and dosing; research-grade material is not the approved product.
5 Frequently asked questions
- What is Lypressin?
- Lypressin is a synthetic peptide and a vasopressin receptor agonist. It is also known as Lysine vasopressin and was first approved by the FDA in 1982.
- How does Lypressin work?
- Lypressin functions as a vasopressin receptor agonist. This means it activates vasopressin receptors, mimicking the action of the natural hormone vasopressin.
- Is Lypressin FDA approved?
- Yes, Lypressin is an FDA-approved compound. It received its initial approval in 1982.
- What is Lypressin studied for?
- Lypressin is studied for its hemodynamic effects, particularly in orthostatic hypotension. It is also explored in the context of vasopressin analogues and for its safety and tolerability in treatments like those for allergic rhinitis in children.
6 References
- Lypressin — compound summary PubChem. View source
- Lypressin — molecule record ChEMBL. View source
- Lypressin — published literature (25 records) PubMed. View source
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