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Ghrelin

From PeptidePlaza, the free peptide reference · Entry #1046 · Metabolic · Sources fetched 2026-09-10 · Editorial standards

Ghrelin (also known as Gastric MLTRP, Ppghrelin, Ghrelin Precursor, Precursor, Ghrelin) is a metabolic research peptide. Ghrelin is a peptide hormone that acts as a ligand for the growth hormone secretagogue receptor (GHSR). It is involved in regulating appetite, metabolism, and growth hormone release.

Ghrelin is a 28-amino acid peptide hormone primarily produced in the stomach, functioning as an endogenous ligand for the growth hormone secretagogue receptor (GHSR). Its primary role involves stimulating growth hormone release from the pituitary gland and regulating energy homeostasis, including appetite stimulation and fat storage. Ghrelin is currently an investigational compound, with extensive research exploring its multifaceted roles. Studies have investigated its relationship to blood glucose, its involvement in gastrointestinal diseases, and its influence on reward and motivation pathways. The literature also focuses on its participation in various feedback systems within the body.

1 Chemical and physical properties

CAS number304853-26-7
Molar mass3370.9 g/mol
Purity (typical)Not independently verified
Storage−20 °C, lyophilised powder, desiccated
SolubilitySterile water / bacteriostatic water

2 Research studies (8)

  1. Biochemistry, Ghrelin
    (2026)
  2. Ghrelin's Relationship to Blood Glucose
    Endocrinology (2019) · Review
  3. Ghrelin in gastrointestinal disease
    Molecular and cellular endocrinology (2011) · Review
  4. Ghrelin, reward and motivation
    Endocrine development (2013) · Review
  5. Ghrelin and feedback systems
    Vitamins and hormones (2008) · Review
  6. Physiological roles of ghrelin on obesity
    Obesity research & clinical practice (2014) · Review
  7. Ghrelin--not just another stomach hormone
    Regulatory peptides (2002) · Review
  8. Ghrelin and the Control of Energy Balance in Females
    Frontiers in endocrinology (2022) · Review

3 Safety and risk profile

3.1 Regulatory status

Ghrelin is currently classified as Investigational. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.

Safety data disclaimer. Safety assessments are based on published literature and are for educational reference only. Clinical evidence varies significantly between peptides. Always consult primary research and current regulatory guidance.

4 Frequently asked questions

What is Ghrelin?
Ghrelin is a 28-amino acid peptide hormone predominantly synthesized in the stomach. It functions as an endogenous ligand for the growth hormone secretagogue receptor (GHSR), playing a key role in several physiological processes.
How does Ghrelin work?
Ghrelin primarily works by binding to and activating the growth hormone secretagogue receptor (GHSR). This activation leads to the stimulation of growth hormone release from the pituitary gland and influences metabolic processes, including appetite regulation.
What is Ghrelin studied for?
Ghrelin is studied for its roles in regulating appetite, metabolism, and growth hormone release. Research also explores its relationship to blood glucose, its involvement in gastrointestinal diseases, and its impact on reward and motivation.
Is Ghrelin FDA approved?
Ghrelin is currently an investigational compound and is not FDA approved for any therapeutic use. Research is ongoing to understand its potential applications.

5 References

  1. Ghrelin — compound summary PubChem. View source
  2. Ghrelin — molecule record ChEMBL. View source
  3. Ghrelin — published literature (13,056 records) PubMed. View source

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6 See also

For research reference only. Not medical advice. Peptides may be regulated or restricted in your jurisdiction. Entry validated by the PeptidePlaza Biomedical Research Desk; see editorial standards.