BPC-157
Body Protection Compound 157
Half-life: ~4 hours (estimated)
Research Profile
Relative research assessments — educational reference only.
Target Receptors
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No human clinical trials exist. All data is from preclinical animal studies. Long-term safety profile is unknown. Not for human use or consumption.
"A 15-amino acid cytoprotective peptide derived from human gastric juice. Widely researched for wound healing, tendon repair, and GI protection across hundreds of animal studies."
Full Description
BPC-157 is a synthetic pentadecapeptide derived from a gastric juice protein. It is stable under gastric acid conditions. Research across hundreds of animal studies demonstrates cytoprotection in various tissue types — including tendon, ligament, muscle, gut, and bone — through multiple overlapping mechanisms: angiogenesis promotion (upregulation of VEGF), nitric oxide pathway modulation, growth hormone receptor sensitization, and direct fibroblast proliferation. Notably effective in models of tendon-to-bone healing, NSAID-induced gut damage, and inflammatory bowel conditions. No human RCTs yet completed.
Mechanism of Action
Promotes angiogenesis via VEGF upregulation; modulates NO synthase pathways; sensitizes GH receptors; directly stimulates fibroblasts and tenocytes. Anti-inflammatory via reduced inflammatory cytokines (TNF-α, IL-6).
Reported Benefits
- • Accelerated tendon and ligament healing in preclinical models
- • Gastrointestinal cytoprotection against NSAID and ethanol damage
- • Promotion of angiogenesis and collagen synthesis
- • Anti-inflammatory effects across multiple tissue types
Potential Side Effects
- • Injection site reactions (erythema, mild pain)
- • Nausea at high oral doses
- • Theoretical concern: angiogenesis promotion could accelerate pre-existing tumors
- • Unknown long-term side effects due to absence of human trials
Frequently Asked Questions
What types of injuries has BPC-157 been shown to help heal?▼
Why is BPC-157 considered unique in regenerative research?▼
Are there human clinical trials for BPC-157?▼
For Research Reference Only
Not medical advice. Peptides may be regulated or restricted in your jurisdiction.
References
- 1.Fabrication and characterization of biocompatible BPC-157 based chitosan hydrogel. PubMed (2026). Arunim, et al.. pubmed.ncbi.nlm.nih.gov/42555375/ ↑
- 2.Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. PubMed (2026). Biçer O, et al.. pubmed.ncbi.nlm.nih.gov/42542926/ ↑
- 3.Stable pentadecapeptide therapy counteracts gentamicin-induced nephrotoxicity via nitric oxide-system modulation: evidence from a triple nitric oxide-agent approach in rats. PubMed (2026). Vukoja I, et al.. pubmed.ncbi.nlm.nih.gov/42533460/ ↑
- 4.Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach. PubMed (2026). Smoday IM, et al.. pubmed.ncbi.nlm.nih.gov/42356491/ ↑
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