Pexiganan Acetate
From PeptidePlaza, the free peptide reference · Entry #1229 · Metabolic · Sources fetched 2026-09-11 · Editorial standards
Pexiganan Acetate (also known as Locilex, MSI-78, Cytolex, Pexiganan (acetate)) is a metabolic research peptide. Pexiganan Acetate is a cell membrane disrupting agent studied for its antimicrobial properties.
Pexiganan Acetate is an antimicrobial peptide that functions as a cell membrane disrupting agent. It is being investigated for its potential therapeutic applications, particularly in the treatment of diabetic foot infections. Research has included studies on its stability in drug formulations and its efficacy in topical applications compared to systemic antimicrobial therapy for mildly infected diabetic foot ulcers. Pexiganan Acetate has reached Phase 3 clinical trials for diabetic foot.
1 Mechanism of action
Cell membrane disrupting agent (disrupting agent)
2 Reported effects
Effects below are those reported in the published literature cited on this page. They are not claims of clinical benefit and not medical advice.
2.1 Indicated / studied for
- Diabetic Foot
3 Chemical and physical properties
| CAS number | 172820-23-4 |
|---|---|
| Molar mass | 2537.2 g/mol |
| Purity (typical) | Not independently verified |
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
4 Research studies (6)
- Pexiganan acetate
Drugs (1998) · Review - Oxidation of the N-terminal gly-residue of peptides: stress study of pexiganan acetate in a drug formulation
Pharmaceutical research (2000) - Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2008) · RCT - USAN Council. List No. 419. New names. Pexiganan acetate
Clinical pharmacology and therapeutics (1999) - Evaluating antimicrobials and implant materials for infection prevention around transcutaneous osseointegrated implants in a rabbit model
Journal of biomedical materials research. Part A (2010) - Counter-ion effect on antistaphylococcal activity and cytotoxicity of selected antimicrobial peptides
Amino acids (2018)
5 Safety and risk profile
5.1 Regulatory status
Pexiganan Acetate is currently classified as Phase 3 clinical trials. It has no approved human indication in the United States; availability elsewhere does not imply demonstrated safety or efficacy.
6 Frequently asked questions
- What is Pexiganan Acetate?
- Pexiganan Acetate is an antimicrobial peptide classified as a cell membrane disrupting agent. It is being developed for its potential use in treating infections.
- How does Pexiganan Acetate work?
- Pexiganan Acetate functions by disrupting the cell membranes of target organisms. This mechanism of action allows it to exert its antimicrobial effects.
- What is Pexiganan Acetate studied for?
- Pexiganan Acetate is primarily studied for its use in treating diabetic foot infections. Clinical trials have investigated its effectiveness as a topical antimicrobial therapy for this condition.
- What is the regulatory status of Pexiganan Acetate?
- Pexiganan Acetate is currently in Phase 3 clinical trials. This stage of development indicates that it is undergoing large-scale testing to confirm its efficacy and safety for its intended use.
7 References
- Pexiganan Acetate — compound summary PubChem. View source
- Pexiganan Acetate — molecule record ChEMBL. View source
- Pexiganan Acetate — published literature (6 records) PubMed. View source
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