Selank

Anxiolytic Nootropic Heptapeptide

Half-life: ~3 minutes (intranasal delivery extends effect)

TP-7Selanc

Research Profile

Research Depth

Potency

Half-Life Score

Selectivity

Stability

Relative research assessments — educational reference only.

Target Receptors

Tuftsin receptorGABA-A (modulatory)BDNF pathway

Critical Research Warning

For educational reference only. Most clinical data is from Russian research groups. Limited Western replication of key findings.

PeptidePlaza Entry #013

"A synthetic analog of the endogenous tetrapeptide Tuftsin. Developed by the Russian Institute of Molecular Genetics. Studied for anxiolytic, nootropic, and immunomodulatory effects without sedation or dependence."

Full Description

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a heptapeptide derived from the immunomodulatory peptide Tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro sequence appended to extend its half-life. Developed at the Russian Institute of Molecular Genetics, it has been studied for anxiolytic effects comparable to benzodiazepines but without sedation, tolerance, or withdrawal. Research indicates it increases BDNF, modulates serotonin and dopamine metabolism, enhances working memory, and exhibits immunomodulatory effects through T-helper cell regulation.

Mechanism of Action

Modulates GABAergic, serotonergic, and dopaminergic systems. Upregulates BDNF expression. Inhibits enkephalin-degrading enzymes. Modulates Th1/Th2 immune balance via tuftsin receptors.

Reported Benefits

• Anxiolytic effects comparable to benzodiazepines without sedation
• Cognitive enhancement via BDNF upregulation
• No tolerance, dependence, or withdrawal observed in studies

Potential Side Effects

• Mild fatigue during initial dosing
• Nasal irritation with intranasal administration
• Limited human data outside Russian clinical studies

Frequently Asked Questions

How does Selank compare to prescription anxiolytics?▼

Research indicates Selank produces anxiolytic effects comparable to benzodiazepines like diazepam, but without the sedation, muscle relaxation, tolerance, or addiction potential. It achieves this through GABA modulation plus additional BDNF and immune pathways not targeted by benzodiazepines.

Does Selank have nootropic effects?▼

Yes, studies show Selank enhances working memory, attention, and cognitive processing speed simultaneously with anxiety reduction — unlike sedating anxiolytics which impair cognition. This dual effect is mediated through BDNF upregulation in the hippocampus.

For Research Reference Only

Not medical advice. Peptides may be regulated or restricted in your jurisdiction.

References

1.Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. PubMed (2022). Konstantinopolsky MA, et al.. pubmed.ncbi.nlm.nih.gov/36322304/ ↑
2.Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. PubMed (2021). Doyno CR, et al.. pubmed.ncbi.nlm.nih.gov/34396551/ ↑
3.Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank. PubMed (2020). Mukhina AY, et al.. pubmed.ncbi.nlm.nih.gov/32651826/ ↑
4.The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. PubMed (2021). Leonidovna YA, et al.. pubmed.ncbi.nlm.nih.gov/32621722/ ↑

Where to Source Selank

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