Corifollitropin Alfa
From PeptidePlaza, the free peptide reference · Entry #1171 · Anti-Aging · Sources fetched 2026-09-11 · Editorial standards
Corifollitropin Alfa is a anti-aging research peptide. Corifollitropin alfa is a follicle stimulating hormone receptor agonist used in controlled ovarian stimulation for assisted reproduction.
Corifollitropin alfa is a synthetic gonadotropin, specifically a follicle stimulating hormone (FSH) receptor agonist. It is designed to provide sustained follicular stimulation, reducing the need for daily injections during controlled ovarian stimulation. The compound is FDA approved and is primarily indicated for use in assisted reproductive techniques, including ovulation induction and in vitro fertilization. Research has focused on its efficacy compared to daily FSH regimens, particularly in women undergoing controlled ovarian stimulation for infertility.
1 Mechanism of action
Follicle stimulating hormone receptor agonist (agonist)
Primary targets: Follicle stimulating hormone receptor
2 Reported effects
Effects below are those reported in the published literature cited on this page. They are not claims of clinical benefit and not medical advice.
2.1 Indicated / studied for
- Ovulation Induction
- Investigative Techniques
- Reproductive Techniques, Assisted
- Infertility
- Hypogonadism
3 Chemical and physical properties
| Purity (typical) | Not independently verified |
|---|---|
| Storage | −20 °C, lyophilised powder, desiccated |
| Solubility | Sterile water / bacteriostatic water |
| Receptors / targets | Follicle stimulating hormone receptor |
4 Research studies (8)
- Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials
Fertility and sterility (2025) · Systematic Review - Corifollitropin alfa for female infertility
Expert opinion on biological therapy (2012) · Review - Corifollitropin alfa versus recombinant follicle-stimulating hormone: an individual patient data meta-analysis
Reproductive biomedicine online (2016) · Meta-Analysis - Corifollitropin alfa: a review of its use in controlled ovarian stimulation for assisted reproduction
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2011) · Review - Corifollitropin alfa compared to daily FSH in controlled ovarian stimulation for in vitro fertilization: a meta-analysis
Journal of ovarian research (2015) · Meta-Analysis - Corifollitropin alfa, a long-acting follicle-stimulating hormone agonist for the treatment of infertility
Current opinion in investigational drugs (London, England : 2000) (2009) · Review - Corifollitropin alfa doses based on body weight: clinical overview of drug exposure and ovarian response
Reproductive biomedicine online (2011) · Review - Impact of patient characteristics on the pharmacokinetics of corifollitropin alfa during controlled ovarian stimulation
British journal of clinical pharmacology (2016) · Meta-Analysis
5 Safety and risk profile
5.1 Regulatory status
Corifollitropin Alfa is currently classified as FDA approved. Approval applies to specific clinical indications and dosing; research-grade material is not the approved product.
6 Frequently asked questions
- What is Corifollitropin alfa used for?
- Corifollitropin alfa is used in controlled ovarian stimulation as part of assisted reproductive techniques. Its indications include ovulation induction, assisted reproductive techniques, infertility, and hypogonadism.
- How does Corifollitropin alfa work?
- Corifollitropin alfa functions as a follicle stimulating hormone (FSH) receptor agonist. It binds to FSH receptors, stimulating follicular development and growth, which is essential for ovulation and successful assisted reproduction procedures.
- Is Corifollitropin alfa FDA approved?
- Yes, Corifollitropin alfa is an FDA-approved compound. It received its first approval in 2010 for its use in reproductive medicine.
- What is the class of Corifollitropin alfa?
- Corifollitropin alfa is classified as a follicle stimulating hormone receptor agonist. It is a synthetic gonadotropin designed to mimic the action of natural follicle-stimulating hormone.
7 References
- Corifollitropin Alfa — molecule record ChEMBL. View source
- Corifollitropin Alfa — published literature (132 records) PubMed. View source
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