#006Anti-Aging

>99.4%

CJC-1295

GHRH Analog (No DAC)

Half-life: ~30 min (No DAC variant)

Modified GRF 1-29Mod GRF(1-29)CJC-1295 No DAC

Research Profile

Research Depth

Potency

Half-Life Score

Selectivity

Stability

Relative research assessments — educational reference only.

Target Receptors

GHRHR

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Critical Research Warning

For educational reference only. Long-term GH elevation and IGF-1 effects on cancer risk and lifespan are areas of active debate.

PeptidePlaza Entry #006

"A tetrasubstituted GHRH analog with four amino acid substitutions that increase receptor affinity and proteolytic resistance. Most commonly studied in combination with Ipamorelin for synergistic GH pulse amplification."

Full Description

CJC-1295 (No DAC) is a modified version of Growth Hormone Releasing Hormone (GHRH), specifically the GHRH(1-29) fragment with four key amino acid substitutions (Ala2→Aib, Gln8→Ala, Ser28→Asn, Gln29→Ala) to improve stability and receptor binding. The "No DAC" designation means it lacks the Drug Affinity Complex modification and therefore has a shorter half-life (~30 min) than DAC versions. It stimulates pituitary somatotrophs to release GH in a physiological pulsatile pattern. Commonly co-administered with GHRP/ghrelin analogs (e.g., Ipamorelin) to amplify endogenous GH pulses.

Mechanism of Action

Binds and activates GHRH receptors (GHRHR) on pituitary somatotrophs, stimulating GH synthesis and release in a pulsatile, physiological pattern. Does not disrupt feedback loops.

Reported Benefits

• Stimulates pulsatile, physiological GH release
• Increases serum IGF-1 levels in dose-dependent manner
• Preserves natural feedback loops unlike exogenous GH

Potential Side Effects

• Injection site reactions and flushing
• Headache and dizziness in some protocols
• Water retention and mild joint discomfort

Frequently Asked Questions

Why is CJC-1295 often combined with Ipamorelin?▼

CJC-1295 amplifies the natural GH pulse signal (via GHRHR), while Ipamorelin suppresses somatostatin (via GHSR). Together they create a larger, longer GH pulse than either can produce alone — a synergistic approach demonstrated in multiple research protocols.

What does "No DAC" mean?▼

The Drug Affinity Complex (DAC) is a chemical modification that binds CJC-1295 to albumin for week-long effects. The No DAC variant lacks this modification, giving it a short half-life (~30 min) that more closely mimics natural GHRH pulsatility.

For Research Reference Only

Not medical advice. Peptides may be regulated or restricted in your jurisdiction.

References

1.The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. PubMed (2026). Dominikowski A, et al.. pubmed.ncbi.nlm.nih.gov/42395176/ ↑
2.Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Implications. PubMed (2026). Villegas Meza AD, et al.. pubmed.ncbi.nlm.nih.gov/42160466/ ↑
3.Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives. PubMed (2026). Renke G, et al.. pubmed.ncbi.nlm.nih.gov/42123471/ ↑
4.Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. PubMed (2026). Mavrych V, et al.. pubmed.ncbi.nlm.nih.gov/42021992/ ↑

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